Co-expression networks identify distinct immune infiltrates in hepatocellular carcinoma
نویسندگان
چکیده
Background The vast majority of hepatocellular carcinoma (HCC) arise in the context of chronic inflammation, especially with hepatitis B or hepatitis C viral infection. Several studies have identified prognostic immune biomarkers in HCC tumors and peritumoral regions. Recently, a Phase 1 trial of a PD-1 inhibitor has demonstrated efficacy in HCC. In order to characterize the diversity of immune microenvironments in HCC, we investigated co-expression networks of immune lineage-specific genes.
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